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Take the time to learn about the potential benefits, the health risks and the many unknowns regarding generic lioresal. It can be frightening to read a list of the side effects of Baclofen. More than a few of my patients have immediately assumed that they would suffer from all of them. The truth is that most people will experience none of them, just the benefits of Baclofen. Side effects vary from person to person and it is impossible to predict exactly how each individual will be affected. Some characteristics and pre-existing conditions are known to increase the risk from certain side effects. Doctors should assess these factors before advising patients on which drugs to choose. The FDA monitors reports of adverse drug reactions and has found no difference in the rates between generic and brand name drugs.

Lioresal (generic name Baclofen) is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness. Lioresal is usually prescribed to patients who are experiencing some of multiple sclerosis' unpleasant symptoms (muscle pain, stiffness and spasm). Lioresal is also indicated in adults and children for the relief of spasticity of voluntary muscle arising from e.g. cerebrovascular accidents, cerebral palsy, meningitis, traumatic head injury.

Lioresal Dosage

Patients are generally advised to start Lioresal at a lower dosage and gradually increase the medication until the beneficial effect is achieved. Starting at 5 mg taken three times a day on the first three days, most patients are taking 20 mg by day twelve. In man, a single 10 mg oral dose of baclofen is rapidly and almost completely absorbed whereas absorption of 20 mg and 40 mg doses is less complete.

Lioresal Drug Interactions

The concomitant administration of baclofen and tricyclic antidepressants may potentiate the pharmacological effects of baclofen, resulting in pronounced muscular hypotonia. The concurrent use of MAO inhibitors and baclofen may result in increased CNS depressant effects; therefore, caution is advised and the dosage of one or both agents should be adjusted accordingly. Isolated cases of increased blood glucose concentrations have reported with baclofen; dosage adjustments of antidiabetic agents may therefore be necessary with combined baclofen treatment. As a general rule, nursing should not be undertaken while a patient is on a drug.

Special Precautions and side effects

Psychotic disorders, schizophrenia, depressive or manic disorders, confusional states or Parkinson's disease may be exacerbated by treatment with Lioresal. Lioresal may also exacerbate epileptic manifestations but can be employed provided appropriate supervision and adequate anticonvulsive therapy are maintained. Lioresal should be used with extreme care in patients already receiving antihypertensive therapy. Lioresal should be used with caution in patients suffering from cerebrovascular accidents or from respiratory, hepatic or renal impairment. Signs of overdose have been observed in patients with renal impairment taking oral Lioresal at doses of more than 5mg per day.