Zithromax, generic name Azithromycin, is a broad-spectrum macrolide antibiotic with a long half-life and excellent tissue penetration. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used in preference to other macrolides for some sexually transmitted and enteric infections. Azithromycin has additional immunomodulatory effects and has been used in chronic respiratory inflammatory diseases for this purpose.
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Infections that may be treated with azithromycin include: community-acquired pneumonia, specific respiratory infections, including pertussis and legionellosis, sexually transmitted infections such as orchitis, pelvic inflammatory disease, bacterial enteritis due to Campylobacter and Salmonella species, cholera and travellers’ diarrhoea.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of azithromycin and other antibacterial drugs, azithromycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
The side effects of azithromycin mostly affect the digestive system. They include diarrhea, nausea, and pain in the abdomen. Some people get very sensitive to sunlight. Others may get headaches, be dizzy or sleepy, or have some problems hearing. Very few people who take azithromycin get these side effects. However, most anti-HIV medications also cause problems in the digestive system. Azithromycin could make those problems worse. Antibiotics kill some helpful bacteria that normally live in the digestive system. You can eat yogurt or take supplements of acidophilus to replace them. It is contraindicated in patients with prior history of hypersensitive reactions to any of the macrolides and in persons with a history of cholestatic liver dysfunction associated with prior use of azithromycin.